Muscle mass and plasma myostatin after exercise training: a substudy of Renal Exercise (RENEXC)-a randomized
Yunan Zhou1, Matthias Hellberg1, Thomas Hellmark1
1Department of Clinical Sciences Lund, Nephrology, Faculty of Medicine, Skåne University Hospital, Lund University, Lund, Sweden.
Summary
Exercise training helps prevent sarcopenia and maintain muscle mass in chronic kidney disease patients. However, the role of myostatin in muscle health and physical function requires further investigation.
Area of Science:
- Nephrology
- Exercise Physiology
- Muscle Biology
Background:
- Sarcopenia is prevalent in chronic kidney disease (CKD) and linked to poor outcomes.
- Myostatin, a muscle growth inhibitor, has an unclear role in exercise response in CKD.
- Understanding exercise effects on sarcopenia and myostatin is crucial for CKD management.
Purpose of the Study:
- To assess the impact of 12-month exercise interventions on sarcopenia and muscle mass in non-dialysis CKD patients.
- To investigate changes in plasma myostatin levels following exercise training.
- To explore the relationship between physical performance, muscle mass, and plasma myostatin.
Main Methods:
- 151 non-dialysis CKD patients (eGFR 23 mL/min/1.73 m²) were randomized to strength or balance/endurance training.
- Body composition was assessed using dual-energy X-ray absorptiometry.
- Plasma myostatin was quantified via ELISA.
Main Results:
- Sarcopenia prevalence remained unchanged; lean mass increased in the balance group but not strength group.
- Whole fat mass decreased in both groups; no significant differences in sarcopenia or body composition between groups.
- Plasma myostatin increased in both groups, with a greater increase in the strength group; baseline myostatin correlated with muscle mass and performance, but this association weakened post-intervention.
Conclusions:
- Exercise training appears effective in preventing sarcopenia and preserving muscle mass in non-dialysis CKD patients.
- The specific role of plasma myostatin in modulating muscle mass and physical performance in CKD warrants additional research.
- Further studies are needed to elucidate the myostatin pathway's involvement in exercise adaptation in CKD.
Related Concept Videos
01:27Exercise and Muscle Performance
2.2K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
2.2K
01:24Serum Studies: Renal Function Tests
319
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
319