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Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

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Published on: February 17, 2023

Tissue Chips in Space: Modeling Human Diseases in Microgravity.

Lucie A Low¹, Marc A Giulianotti²

¹National Center for Advancing Translational Sciences, National Institutes of Health, 6701 Democracy Boulevard, 9th Floor NCATS Suite, Bethesda, Maryland, 20892, USA. Lucie.low@nih.gov.

Pharmaceutical Research

|December 19, 2019

Summary

This summary is machine-generated.

Microphysiological systems (MPS), or tissue chips, are advanced in vitro models. The Tissue Chips in Space initiative leverages these models on the International Space Station (ISS) for biomedical research.

Keywords:

Disease modeling International Space Station Microgravity Microphysiological systems Organs on chips Tissue chips

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Published on: May 25, 2021

Area of Science:

Biomedical Engineering
Cell Biology
Tissue Engineering

Background:

Microphysiological systems (MPS), also known as organs-on-chips or tissue chips, are advanced in vitro models.
MPS offer improved solutions for modeling human physiology and disease compared to traditional methods.
These systems are crucial for research areas where conventional cell cultures and animal models are insufficient.

Purpose of the Study:

Introduce the NIH Tissue Chips in Space initiative.
Provide an overview of the collaboration between NIH and the ISS National Laboratory.
Highlight progress and challenges in developing MPS for space-based research.

Main Methods:

Leveraging advances in cell biology, tissue engineering, and microfabrication.
Coordinated efforts between the National Center for Advancing Translational Sciences (NCATS) and the ISS U.S. National Laboratory.
Launching and utilizing MPS platforms onboard the International Space Station (ISS).

Main Results:

Progress in addressing scientific and technical challenges for space-based MPS.
Demonstration of MPS capabilities in the unique space environment.
Facilitation of novel research opportunities through the Tissue Chips in Space program.

Conclusions:

The Tissue Chips in Space program represents a significant advancement for MPS technology.
This initiative holds substantial potential for broader biomedical and health research.
Space-based MPS research is poised to expand our understanding of human physiology and disease.