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Personalized pediatric anesthesia and pain management: problem-based review
Senthil Packiasabapathy1, Valluvan Rangasamy1, Nicole Horn1
1Department of Anesthesia, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN 46202, USA.
Pharmacogenomics
|December 19, 2019
Summary
Pharmacogenetics optimizes drug therapy by considering genetic variations in drug response. This review focuses on key pharmacogenetic findings in anesthesia and pain management, particularly for pediatric patients.
Area of Science:
- Pharmacology
- Genetics
- Anesthesiology
Background:
- Pharmacogenetics investigates how genes affect drug responses, enabling personalized medicine.
- While oncology led personalized medicine, anesthesia is increasingly adopting it.
- Known genetic links in anesthesia include malignant hyperthermia and succinylcholine reactions.
Purpose of the Study:
- To review significant pharmacogenetic associations in anesthesia and pain management.
- To highlight advancements in personalized pharmacotherapy within anesthesiology.
- To emphasize the role of pharmacogenetics in pediatric anesthesia.
Main Methods:
- Literature review of pharmacogenetic studies in anesthesia.
- Analysis of prominent pharmacogenetic associations.
- Focus on evidence relevant to pediatric anesthesia and pain management.
Main Results:
- An expanding body of pharmacogenetic evidence exists in anesthesia over the last two decades.
- Classical examples of genetically mediated reactions are well-established.
- Recent research continues to uncover new pharmacogenetic links.
Conclusions:
- Pharmacogenetics is crucial for tailoring drug therapy in anesthesia.
- Personalized medicine approaches are gaining traction in anesthesiology.
- Further research, especially in pediatric populations, is warranted.
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