Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

13.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
13.9K
Blood Transfusion01:15

Blood Transfusion

2.0K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.0K
Tissue Transplantation01:24

Tissue Transplantation

831
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
831
Disorders of Hemostasis01:24

Disorders of Hemostasis

1.9K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.9K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.2K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.2K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

326
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
326

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pathogenic PF4/Polyanion ELISA-Negative Antibodies in HIT.

American journal of hematology·2026
Same author

Non-PF4/heparin-binding, platelet-activating antibodies in heparin-induced thrombocytopenia.

Blood·2026
Same author

Pathogenic PF4/Polyvinylsulfonate ELISA-negative Antibodies in HIT.

medRxiv : the preprint server for health sciences·2025
Same author

PF4-dependent P-selectin expression assay in comparison to the heparin-induced platelet activation assay for the diagnosis of heparin-induced thrombocytopenia.

Transfusion·2025
Same author

Management challenge of a rare concomitant platelet glycoprotein IV/CD36 and IIb/IIIa deficiencies: Case illustration.

Transfusion·2025
Same author

O-linked sialic acid residues on platelet membrane glycoprotein IIb mask the human HPA-9b alloepitope.

Blood·2023

Related Experiment Video

Updated: Jan 1, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.5K

Post-Transfusion Purpura: Current Perspectives.

Jaleah Hawkins1, Richard H Aster2,3, Brian R Curtis2,3

  • 1Versiti, Blood Center of Michigan, Grand Rapids, MI, USA.

Journal of Blood Medicine
|December 19, 2019
PubMed
Summary
This summary is machine-generated.

Post transfusion purpura (PTP) is a rare adverse event causing severe thrombocytopenia. Diagnosis requires identifying platelet antibodies, and treatment with Intravenous Immunoglobulin (IVIG) is effective.

Keywords:
platelet antibodiesthrombocytopeniatransfusion reactions

More Related Videos

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

1.1K
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

12.4K

Related Experiment Videos

Last Updated: Jan 1, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.5K
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

1.1K
Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

12.4K

Area of Science:

  • Hematology
  • Immunology
  • Transfusion Medicine

Background:

  • Post transfusion purpura (PTP) is a rare but severe adverse event following blood transfusions.
  • Characterized by profound thrombocytopenia, PTP can lead to significant bleeding and hemorrhage.
  • Diagnosis is challenging due to overlapping symptoms with other thrombocytopenic syndromes, leading to underdiagnosis and underreporting.

Purpose of the Study:

  • To review the diagnostic challenges and current understanding of PTP pathogenesis.
  • To highlight the established treatment protocols for PTP.
  • To emphasize precautions for future transfusions in patients with a history of PTP.

Main Methods:

  • Literature review of PTP cases and pathogenesis theories.
  • Analysis of diagnostic criteria, including laboratory evidence of platelet antibodies.
  • Evaluation of treatment efficacy, particularly Intravenous Immunoglobulin (IVIG).

Main Results:

  • PTP diagnosis requires laboratory confirmation of platelet-specific antibodies.
  • The paradoxical destruction of both transfused and autologous platelets remains incompletely understood.
  • Intravenous Immunoglobulin (IVIG) is a highly effective treatment, despite limited understanding of PTP etiology.

Conclusions:

  • Accurate diagnosis of PTP relies on clinical suspicion coupled with laboratory confirmation of platelet antibodies.
  • While PTP pathogenesis is not fully elucidated, IVIG is the standard and effective treatment.
  • Patients with a history of PTP require careful consideration for future transfusions due to rare recurrence risks.