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Updated: Jan 1, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

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The Evolving Role of Brentuximab Vedotin in Classical Hodgkin Lymphoma

Catherine Lai1, Adrese Michael Kandahari1, Chaitra Ujjani2

  • 1Lombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington, DC, USA.

Blood and Lymphatic Cancer : Targets and Therapy
|December 19, 2019
PubMed

The arrival of the CD30 directed antibody-drug conjugate, brentuximab vedotin (BV), has altered the approach to patients with classical Hodgkin lymphoma. Since initial approval in 2011, BV has been extensively studied in previously untreated and relapsed/refractory patients. Treatment indications for the antibody-drug conjugate have been expanded from the previously treated population to include maintenance therapy after autologous stem cell transplantation and recently, combination with chemotherapy in newly diagnosed advanced stage patients. This article will review the evolution of BV in classical Hodgkin lymphoma, detailing the studies that led to the approved indications and discussion of recent trials in combination with chemotherapy and immunotherapy.

Keywords:
CD30antibody-drug conjugatebrentuximab vedotinclassical Hodgkin lymphomaimmunotherapynovel therapies

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