Host-microbe interactions: Profiles in the transcriptome, the proteome, and the metabolome

Area of Science:

• Periodontology
• Molecular Biology
• Microbiome Research

Background:

• Periodontal diseases involve complex host-microbe interactions.
• Omics technologies (transcriptomics, proteomics, metabolomics) are increasingly used in periodontal research.
• These studies provide molecular insights into disease pathogenesis.

Purpose of the Study:

• To review current molecular findings in periodontal disease using omics approaches.
• To highlight the role of omics in understanding host immune response, tissue homeostasis, and metabolic processes.
• To emphasize the potential of integrating omics for improved diagnosis and treatment.

Main Methods:

• Review of studies utilizing transcriptomics, proteomics, and metabolomics.
• Analysis of molecular data related to periodontal health and disease.
• Synthesis of findings on host-microbe interactions and metabolic pathways.

Main Results:

• Omics studies have significantly increased, revealing new insights into periodontal disease pathogenesis.
• Key findings include modulation of host immune response and tissue homeostasis.
• Complex metabolic processes of the host and oral microbiome are elucidated.

Conclusions:

• Integration of omics approaches broadens the understanding of periodontal disease mechanisms.
• These molecular insights are crucial for advancing diagnosis and treatment strategies.
• Future research integrating omics will improve management of various periodontal conditions.