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Association between Dialysis Modality and Cardiovascular Diseases: A Comparison between Peritoneal Dialysis and

Masataka Banshodani1, Hideki Kawanishi2, Misaki Moriishi2

  • 1Department of Artificial Organs, Akane-Foundation, Tsuchiya General Hospital, Hiroshima, Japan, m-banshodani@tsuchiya-hp.jp.

Blood Purification
|December 19, 2019
PubMed

Insights

Peritoneal dialysis (PD) increases the risk of cardiovascular disease (CVD) hospitalization and death in end-stage kidney disease (ESKD) patients compared to hemodialysis (HD). Careful fluid management is crucial for PD patients to prevent cardiovascular events.

Area of Science:

  • Nephrology
  • Cardiology
  • Epidemiology

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality in patients with end-stage kidney disease (ESKD).
  • Dialysis modality, including peritoneal dialysis (PD) and hemodialysis (HD), may influence CVD risk in ESKD patients.

Purpose of the Study:

  • To investigate the association between dialysis modality (PD vs. HD) and the risk of CVD-related emergency hospitalization and mortality in ESKD patients.
  • To identify risk factors for CVD events in patients undergoing different dialysis treatments.

Main Methods:

  • A retrospective observational cohort study design was employed.
  • Propensity score matching was used to compare patients undergoing PD versus HD.
  • Cox proportional hazards regression models were utilized to evaluate risk factors for CVD events.

Main Results:

  • Patients on PD had significantly higher rates of emergency hospitalization for overall CVDs and pulmonary edema compared to those on HD.
  • All-cause and CVD-related mortality were significantly higher in the PD group.
  • PD was identified as a significant predictor of both emergency hospitalization and mortality for CVDs.

Conclusions:

  • Peritoneal dialysis is associated with an increased risk of cardiovascular disease hospitalization and mortality in ESKD patients.
  • Strict management of fluid balance in PD patients may be essential for mitigating cardiovascular risks.
  • These findings highlight the importance of considering dialysis modality when assessing CVD risk in ESKD.
Abstract

Keywords:
Cardiovascular diseaseHemodialysisHospitalizationMortalityPeritoneal dialysis

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