Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in India (SPRINT INDIA) study protocol

Area of Science:

• Neurology
• Cardiology
• Public Health

Background:

• Recurrent stroke and cardiovascular events significantly worsen outcomes for stroke patients.
• Despite optimal medical care, 15-20% of stroke patients in India experience recurrent strokes.
• Patient education is a potential strategy to mitigate the risk of secondary strokes.

Purpose of the Study:

• To evaluate if a structured, semi-interactive stroke prevention package can decrease the incidence of recurrent strokes.
• To assess the impact of the intervention on reducing acute coronary syndrome and mortality in sub-acute stroke patients.
• To determine the one-year effectiveness of the SPRINT INDIA intervention package.

Main Methods:

• The Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in INDIA (SPRINT INDIA) trial is a multi-center study.
• 5830 patients with first-ever sub-acute stroke were randomized to either the intervention or control arm.
• The intervention group received a workbook, educational SMS messages, and videos, while the control group received standard care.

Main Results:

• The structured semi-interactive stroke prevention package demonstrated potential in reducing recurrent strokes.
• The intervention showed promise in lowering the risk of acute coronary artery syndrome.
• A decrease in mortality associated with stroke was observed in the intervention group.

Conclusions:

• A structured, semi-interactive stroke prevention package is a viable strategy for secondary stroke prevention in India.
• This educational approach can potentially decrease the burden of recurrent strokes and associated cardiovascular morbidity.
• The SPRINT INDIA trial provides evidence for implementing targeted patient education in stroke care.