75-degree non-mydriatic single-volume optical coherence tomographic angiography

Area of Science:

• Ophthalmology
• Medical Imaging
• Biomedical Engineering

Background:

• Optical coherence tomography (OCT) and OCT angiography (OCTA) are advanced imaging techniques providing high-resolution, 3D visualization of ocular structures and vasculature.
• Current OCT and OCTA systems often have limited fields of view compared to fundus photography, hindering comprehensive retinal assessment.
• Montaging techniques, used to expand field of view, can introduce artifacts and increase acquisition time.

Purpose of the Study:

• To present a novel high-speed, high-sensitivity swept source laser-based system for OCT and OCTA imaging.
• To demonstrate the system's capability of acquiring wide, 75-degree field of view images in a single scan.
• To achieve capillary-level image quality for improved diagnostic potential.

Main Methods:

• Development of a swept source laser system optimized for speed and sensitivity.
• Implementation of an optimized scanning protocol to acquire 75-degree field of view OCT and OCTA data.
• Non-mydriatic imaging to enhance patient comfort and accessibility.

Main Results:

• Successful acquisition of non-mydriatic 75-degree field of view OCT and OCTA images in a single scan.
• Demonstration of capillary-level image quality without the need for montaging.
• High-speed and high-sensitivity performance validated.

Conclusions:

• The developed system overcomes the field-of-view limitations of conventional OCT and OCTA.
• Capillary-level imaging across a wide field of view can significantly enhance the early detection of ocular pathologies.
• This technology offers valuable data for monitoring disease progression and treatment response in ophthalmology.