Related Experiment Video
Updated: Jan 1, 2026

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
Mechanisms for heart failure in systemic right ventricle
Lauren Andrade1,2, Matthew Carazo3, Fred Wu4,5
1Division of Cardiology, University of Pennsylvania, Philadelphia, PA, USA. lauren.andrade@pennmedicine.upenn.edu.
Abstract:
There are two predominant scenarios where the right ventricle acts as the systemic ventricle, namely congenitally corrected transposition of the great arteries (CC-TGA) and patients with D-transposition of the great arteries (D-TGA) who have undergone an atrial switch operation. There is evidence that having a right ventricle in the systemic position predisposes to the development of heart failure. In this review, we aim to explore the proposed mechanisms and pathophysiology for heart failure in patients with a systemic right ventricle in these two subsets of patients.
More Related Videos
Related Concept Videos
Heart Failure II: Pathophysiology
Pathophysiology of Heart Failure
Mitral Regurgitation I: Introduction
Heart Failure I: Introduction
Heart Failure III: Clinical Manifestations
Mitral Stenosis I: Introduction

