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Toll-like receptor 10 rs4129009 gene polymorphism is associated with post-bronchiolitis lung function in adolescence

Riikka Riikonen1, Matti Korppi1, Sari Törmänen1

  • 1Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.

Acta Paediatrica (Oslo, Norway : 1992)
|December 20, 2019
PubMed

Insights

Genetic variations in Toll-like receptor 10 (TLR10) influence long-term lung function in children previously hospitalized for bronchiolitis. The variant TLR10 genotype is linked to better lung function outcomes in this cohort.

Area of Science:

  • Immunology
  • Pulmonology
  • Genetics

Background:

  • Bronchiolitis is a common childhood respiratory infection.
  • Long-term respiratory sequelae after severe bronchiolitis are a concern.
  • Toll-like receptors (TLRs) play a role in innate immunity and respiratory infections.

Purpose of the Study:

  • To investigate the association between polymorphisms in Toll-like receptor (TLR) 2 subfamily genes and lung function.
  • To assess lung function in children previously hospitalized for bronchiolitis during infancy.
  • To evaluate spirometry measurements at 10-13 years of age in relation to TLR gene variants.

Main Methods:

  • Prospective cohort study of 166 former bronchiolitis patients.
  • Structured questionnaires and clinical follow-up including spirometry.
  • Genotyping for polymorphisms in TLR1, TLR2, TLR6, and TLR10 genes.

Main Results:

  • The wild (AA) genotype of TLR10 rs4129009 was associated with lower FEV1/FVC ratios.
  • This association persisted both before and after bronchodilator administration.
  • Combined analysis of TLR10, TLR2, and TLR1 genotypes showed lowest FEV1/FVC in subjects with the wild TLR10 rs4129009 genotype.

Conclusions:

  • Children with the variant TLR10 rs4129009 genotype exhibited superior lung function.
  • This suggests that TLR10 genetic variations may influence long-term respiratory health post-bronchiolitis.
  • The findings highlight a potential genetic predisposition affecting lung function recovery.
Abstract

Keywords:
bronchiolitischildlung functionspirometrytoll-like receptor

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