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Analog-sensitive cell line identifies cellular substrates of CDK9

Tim-Michael Decker1,2, Ignasi Forné3, Tobias Straub4

  • 1Department of Molecular Epigenetics, Helmholtz Center Munich and Center for Integrated Protein Science Munich (CIPSM), Germany.

Oncotarget
|December 21, 2019
PubMed
Summary

Cyclin-dependent kinase 9 (CDK9) activity was quantitatively assessed in cells, revealing 120 substrates and a role in transcription-coupled splicing. Cellular context significantly influences CDK9 substrate selection.

Keywords:
CDK9RNA splicingphosphoproteomicsprotein kinasetranscription

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