Related Experiment Video

Updated: Jan 1, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.9K

Treatment of hepatitis C in selected clinical settings

Urszula Ołdakowska-Jedynak1, Jolanta Małyszko1

  • 1Department of Nephrology, Dialysis and Internal Diseases, Warsaw Medical University, Warsaw, Poland.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|December 21, 2019
PubMed

Insights

This review updates Hepatitis C virus (HCV) treatment strategies, focusing on European Association for the Study of the Liver (EASL) recommendations for acute and chronic infections in special patient groups.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Hepatitis C virus (HCV) infection poses significant challenges, particularly in specific patient populations.
  • Optimal treatment strategies require continuous updates based on evolving research and guidelines.

Purpose of the Study:

  • To review current Hepatitis C virus (HCV) treatment strategies for compelling indications.
  • To provide an update on the literature, emphasizing European Association for the Study of the Liver (EASL) recommendations.
  • To focus on HCV management in patients with immune complex-mediated manifestations, chronic kidney disease (CKD), end-stage renal disease (ESRD), and solid organ transplant recipients.

Main Methods:

  • Literature review
  • Analysis of European Association for the Study of the Liver (EASL) guidelines
  • Focus on specific clinical settings and patient cohorts

Main Results:

  • The review synthesizes current optimal management approaches for acute and chronic HCV infections.
  • It highlights tailored treatment considerations for patients with specific comorbidities and complications.
  • EASL recommendations provide a framework for managing HCV in complex cases.

Conclusions:

  • Effective Hepatitis C virus (HCV) treatment requires individualized strategies, especially in patients with CKD, ESRD, or those who have undergone transplantation.
  • Adherence to updated EASL guidelines is crucial for optimizing patient outcomes.
  • Further research is needed to refine HCV treatment in immune-mediated conditions.

Keywords:
HCV therapychronic kidney diseaserenal replacement therapydirect-acting antiviral regimenssolid organ transplantation

More Related Videos

A Protocol for Analyzing Hepatitis C Virus Replication13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.6K
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

7.3K

Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
322
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
178
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
143
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.1K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
266
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
485