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Chaperoning STAT3/5 by Heat Shock Proteins: Interest of Their Targeting in Cancer Therapy

Gaëtan Jego1,2, François Hermetet1,2, François Girodon1,2,3

  • 1INSERM, LNC UMR1231, team HSP-Pathies, University of Bourgogne Franche-Comté, F-21000 Dijon, France.

Cancers
|December 22, 2019
PubMed

Insights

Molecular chaperones, or heat shock proteins (HSPs), regulate cell fate and cancer progression by interacting with STAT3/STAT5 signaling. Targeting HSPs may offer a novel therapeutic strategy against cancer.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Oncology

Background:

  • Cellular survival, growth, and proliferation depend on external signals and proper protein folding.
  • Molecular chaperones, including heat shock proteins (HSPs), are critical for protein quality control.
  • HSPs interact with STAT3/STAT5 signaling, influencing cancer cell tumorigenesis and immune suppression.

Purpose of the Study:

  • To review the intricate relationship between HSPs and the STAT3/STAT5 signaling pathway.
  • To explore the role of HSPs in cancer cell proliferation, survival, and immune evasion.
  • To evaluate the therapeutic potential of targeting HSPs in cancer treatment.

Main Methods:

  • Literature review focusing on the interplay between HSPs (HSP27, HSP70, HSP90, HSP110) and STAT3/STAT5 signaling.
  • Analysis of how HSPs modulate STAT3/STAT5 activation and vice versa.
  • Discussion of the therapeutic implications of targeting HSPs in oncogenic pathways.

Main Results:

  • HSPs significantly influence STAT3 and STAT5 activation, impacting cancer cell characteristics.
  • STAT signaling pathways, in turn, modulate the expression of HSPs.
  • The complex interplay suggests a potential vulnerability in cancer cells that can be exploited therapeutically.

Conclusions:

  • Targeting specific HSPs presents a promising strategy to inhibit STAT3/STAT5 oncogenic functions.
  • Further research is needed to identify the most effective HSP targets for cancer therapy.
  • Understanding this molecular crosstalk is crucial for developing novel anti-cancer treatments.
Keywords:
chaperonesheat shock proteinsstabilizationtargeted therapy

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