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Published on: November 2, 2015
Intermittent hypoxia and bronchial hyperreactivity
Thomas M Raffay1, Richard J Martin1
1Rainbow Babies & Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106-6010, USA.
Insights
Premature infants often experience intermittent hypoxemia, increasing their risk for childhood airway hyperreactivity and wheezing. Research explores how these hypoxic events impact respiratory health and utilizes newborn models to understand disease pathways.
Area of Science:
- Neonatal respiratory health
- Pediatric pulmonology
- Hypoxia research
Background:
- Premature neonates face high risks for childhood airway hyperreactivity and wheezing.
- Intermittent hypoxic events are common in early life for these infants.
- Intermittent hypoxemia is linked to adverse outcomes like bronchopulmonary dysplasia.
Purpose of the Study:
- To review the incidence of intermittent hypoxia in premature neonates.
- To explore the role of intermittent hypoxia in respiratory morbidity.
- To examine translational newborn models investigating hypoxia's contribution to respiratory disease.
Main Methods:
- Literature review on intermittent hypoxia in neonates.
- Analysis of associations between hypoxemia and respiratory outcomes.
- Overview of current translational newborn models.
Main Results:
- Intermittent hypoxia is frequently observed in premature infants.
- Hypoxemia is associated with bronchopulmonary dysplasia, wheezing, and asthma medication use.
- Translational models are being developed to study hypoxia-induced respiratory disease.
Conclusions:
- Intermittent hypoxia is a significant risk factor for respiratory morbidity in premature infants.
- Understanding hypoxia pathways is crucial for developing interventions.
- Newborn models offer valuable insights into respiratory disease mechanisms.
Abstract:
The premature neonate is at high risk for childhood airway hyperreactivity and episodes of wheezing. Intermittent hypoxic events are frequently observed during the first weeks and months of life in these infants. Intermittent hypoxemia has been associated with adverse outcomes in extremely premature infants; including the diagnosis of bronchopulmonary dysplasia, reported wheezing, and use of prescription asthma medications. We review the incidence of intermittent hypoxia, their potential role in short and longer term respiratory morbidity, and the translational newborn models now being used to investigate common pathways by which intermittent hypoxia contributes to respiratory disease.
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