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Chemokines in human obesity
Volatiana Rakotoarivelo1, Bhavesh Variya1, Marie-France Langlois2
1Department of Immunology and Cell Biology, CRCHUS, Sherbrooke, QC, Canada.
Cytokine
|December 23, 2019
Summary
Obesity and type 2 diabetes are linked to chronic inflammation. This review examines chemokines CCL2 and CCL5 in human obesity, highlighting their role in immune cell recruitment.
Area of Science:
- Immunology
- Endocrinology
- Metabolic diseases
Background:
- Obesity and type 2 diabetes are associated with chronic inflammation.
- Despite research on inflammatory mediators, clinical outcomes have been disappointing.
- Immune cell recruitment contributes to chronic inflammation in murine models.
Purpose of the Study:
- To review observations on CCL2 and CCL5 in human obesity.
- To investigate the role of specific chemokines in immune cell recruitment in obesity.
- To address the lack of clear evidence for chemokine differential expression in human obesity.
Main Methods:
- Literature review focusing on human obesity studies.
- Analysis of existing data on CCL2 and CCL5 expression and function.
- Discussion of immune cell recruitment mechanisms.
Main Results:
- Chemokines CCL2 and CCL5 are implicated in immune cell recruitment in obesity.
- Evidence suggests differential expression of these chemokines contributes to chronic inflammation.
- Further research is needed to clarify their precise roles in human obesity.
Conclusions:
- Chemokines CCL2 and CCL5 are important in the inflammatory processes of human obesity.
- Understanding chemokine roles may lead to improved therapeutic strategies.
- Targeting these chemokines could mitigate obesity-associated inflammation.
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