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Published on: May 23, 2025
Distribution of Helicobacter pylori infection and abnormal body- mass index (BMI) in a developing country
Basit Siddiqui1, Javed Yakoob2, Zaigham Abbas3
1Aga Khan University Hospital, Karachi, Pakistan. dr.basit.siddiqui@gmail.com.
Introduction:
Helicobacter pylori is prevalent in developing nations. We determined the prevalence of H. pylori infection in relation to body-mass index (BMI) of dyspeptic patients and related comorbid conditions.
Methodology:
In a cross-sectional study, dyspeptic patients were enrolled and tested for H. pylori infection. "Underweight" was defined as BMI lower than 18.4; "Healthy" 18.5 to 23; "Overweight" 23.1-27.9; and "Obese" greater than 28.
Results:
Six hundred and ninety-eight patients were included, with a mean age of 44 ± 16 years. Males were 373/698, 53%. H. pylori was positive in 399/698, 57%. Underweight were 36 (5%); BMI-healthy 168 (24%); overweight 236 (34%) and obese 258 (37%). H. pylori infection was present in 65/273 BMI-healthy patients ; 24% compared to obese 208/273; 76% (P < 0.001). In the H. pylori- positive with a "healthy" BMI, dyslipidemia was seen in 6/65; 8% compared to obese 53/208; 25% (P = 0.005); type 2 diabetes in 8/65; 12% with a "healthy" BMI compared to obese 54/208; 26% (P = 0.022) and coronary artery disease in 4/65; 6% of BMI-healthy compared to obese 38/208; 18% patients (P = 0.018). Multivariate analysis showed that age 31-50 years (OR 1.77, 95% CI 1.13-2.77), BMI > 23.1 (OR 2.91, 95% CI infection. 2.01-4.20), and type 2 diabetes (OR 2.41, 95% CI 1.43-4.06) were risk factors for H. pylori.
Conclusions:
H. pylori infection was prevalent in the 31-50-year age group. Abnormal BMI was associated with H. pylori infection.
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