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Updated: Jan 1, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering

Yue-Peng Shang1, Qi Chen1, Ai-Tao Li2

  • 1State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, Shanghai, 200237, China.

Journal of Biotechnology
|December 24, 2019
PubMed

Keywords:
Asymmetric reductionHaloketone reductaseProtein engineeringSubstrate inhibitionX-ray crystal structure

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