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Integron-Related Resistance in New Emerged Staphylococcus lugdunensis Infection in Burn Patients
Neda Pirbonyeh1, Amir Emami1, Abdollah Bazargani2
1Burn and Wound Healing Research Center, Microbiology Department, Shiraz University of Medical Sciences, Iran.
Abstract:
Staphylococcus lugdunensis is a coagulase-negative Staphylococcus species that may cause various infections with unusual severity. In spite of the administration of various antibiotics, infections caused by such bacteria are become resistant significantly. Transmission of antibiotic resistance genes, especially by Integron structures, exacerbates the prevalence of resistant strains. To investigate the antibiotic susceptibility pattern of S. lugdunensis as a new emergence in burns, the presence of integron classes (I, II, III) was performed in recent study. Sampling for this study was carried out over a period of 13 months (January 2017 to February 2018) from Amir-Al-Momenin burn center of southwest of Iran, affiliated with Shiraz University of Medical Sciences. Twenty-eight isolates of S. lugdunensis were confirmed by phenotypic tests. The presence of integron classes was evaluated by PCR technique and specific primers. The majority of studied infectious agents were seen in ICU with 28.57%. The prevalence of class I and II integrons was 7 (25.00%) and 2 (7.14%), respectively, in S. lugdunensis isolates, whereas no integron III was found. No significant association was seen between antibiotic resistance and the present integrons (P > .05). Since the prevalence of S. lugdunensis strains as a new emergence infection is increasing in clinical settings especially burns, preventing drug resistance in these isolates is inevitable. So knowing the epidemiology pattern of new emerging infections and their resistant pattern is very helpful in infection control and save hospitalized patients life.
Insights
Staphylococcus lugdunensis infections are increasingly resistant to antibiotics. This study found Class I and II integrons in some resistant strains, highlighting the need for infection control in burn units.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Staphylococcus lugdunensis, a coagulase-negative Staphylococcus, causes severe infections with growing antibiotic resistance.
- Integrons are mobile genetic elements that contribute to the spread of antibiotic resistance genes.
- Understanding S. lugdunensis antibiotic susceptibility and integron prevalence is crucial for infection control, especially in burn patients.
Purpose of the Study:
- To investigate the antibiotic susceptibility patterns of Staphylococcus lugdunensis isolates from burn patients.
- To determine the prevalence of integron classes (I, II, and III) in S. lugdunensis isolates.
- To explore the association between integron presence and antibiotic resistance in these strains.
Main Methods:
- Phenotypic tests were used to confirm 28 S. lugdunensis isolates.
- Polymerase Chain Reaction (PCR) with specific primers was employed to detect integron classes.
- Isolates were collected from burn patients over a 13-month period.
Main Results:
- Class I integrons were detected in 25% of S. lugdunensis isolates, and Class II integrons in 7.14%.
- No Class III integrons were found in any of the isolates.
- No significant association was observed between the presence of integrons and antibiotic resistance (P > .05).
Conclusions:
- Staphylococcus lugdunensis is an emerging cause of infection in burn units, exhibiting significant antibiotic resistance.
- The presence of Class I and II integrons suggests a potential mechanism for resistance gene dissemination.
- Further research and effective infection control strategies are necessary to manage S. lugdunensis infections and combat antimicrobial resistance in clinical settings.
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