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Enzyme-responsive fluorescent camptothecin prodrug/polysaccharide supramolecular assembly for targeted cellular
Yu-Hui Zhang1, Ying-Ming Zhang, Xianliang Sheng
1College of Science, Inner Mongolia Agricultural University, Hohhot 010018, P. R. China.
Chemical Communications (Cambridge, England)
|December 24, 2019
Abstract:
A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane-naphthalimide fluorescent camptothecin prodrug (AdaCPT) and β-CD modified hyaluronic acid (HACD) was constructed, possessing low cellular cytotoxicity and exhibiting targeted cellular imaging and controlled drug release at specific sites while providing a concurrent means for the real-time tracking of drug delivery.
