Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Immune Surveillance by NK Cells and Phagocytes

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Expression Patterns of Matricellular Proteins in Metastatic Breast Cancer at the Background of Metabolic Syndrome.

Experimental oncology·2025

Same author

Factors that Determined a Positive Response to Resynchronization Therapy in Patients With Chronic Heart Failure and Cardiac Dyssynchrony. One Center Experience.

Kardiologiia·2024

Same author

Experimental oncology·2023

Same author

BIOMAGNETISM OF DRUG-SENSITIVE AND DRUG-RESISTANT MALIGNANT TUMORS AFTER INJECTION OF FERROMAGNETIC NANOCOMPOSITE.

Experimental oncology·2023

Same author

АNTIMETASTATIC EFFECT OF B. SUBTILIS IMV B-7724 LECTIN OBSERVED IN LEWIS LUNG CARCINOMA MODEL.

Experimental oncology·2022

Same author

HUMAN MICROBIOTA AND BREAST CANCER.

Experimental oncology·2022

Search research articles

Related Experiment Video

Updated: Jan 1, 2026

In Vitro Assay to Study Tumor-macrophage Interaction

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

Macrophages - a perspective target for antineoplastic immunotherapy.

О М Karaman¹, A V Ivanchenko¹, V F Chekhun¹

¹R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology NAS of Ukraine, Kyiv 03022, Ukraine.

Experimental Oncology

|December 24, 2019

Summary

This review examines macrophage polarization (M1/M2 types) and its role in cancer development. Determining macrophage states in tumors is crucial for understanding cancer progression and prognosis.

More Related Videos

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion

Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion

Published on: October 20, 2016

Related Experiment Videos

Last Updated: Jan 1, 2026

In Vitro Assay to Study Tumor-macrophage Interaction

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion

Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion

Published on: October 20, 2016

Area of Science:

Immunology
Oncology
Cell Biology

Background:

Macrophages exhibit diverse functional phenotypes, broadly classified as M1 (pro-inflammatory) and M2 (anti-inflammatory).
Macrophage polarization is a dynamic process influenced by the tumor microenvironment.
These cells play a significant role in tumor initiation, progression, and metastasis.

Purpose of the Study:

To review the functional/phenotypic M1/M2 macrophage types and their chimeric forms.
To elucidate the molecular mechanisms governing macrophage polarization.
To analyze the prognostic value of M1/M2 macrophage presence, density, and location in tumor tissues.

Main Methods:

Literature review of existing data on macrophage polarization and cancer.
Analysis of molecular mechanisms driving M1/M2 differentiation.
Evaluation of studies correlating M1/M2 cell presence with tumor prognosis.
Inclusion of original research data on macrophage functional states in vivo.

Main Results:

M1/M2 macrophages and their intermediate forms are implicated in malignant tumor development.
The density and location of M1/M2 macrophages within tumor tissue offer prognostic insights.
Functional states, including nitric oxide (NO) levels and arginase activity, are critical indicators.

Conclusions:

Understanding macrophage polarization is essential for cancer research.
Assessing the dynamic functional/phenotypic state of M1/M2 macrophages in various biological niches is necessary.
Macrophage-based biomarkers hold potential for cancer prognosis and therapeutic strategies.