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Association of CYP1A1 rs1048943 Polymorphism with Prostate Cancer in Iraqi Men Patients
Wisam H Hoidy1, Ferdous A Jaber2, Mohammed A Al-Askari3
1Department of Chemistry, College of Education, University of Al-Qadisiyah, Al-Qadisiyah City, Iraq.
Objective:
The purpose of this study was to evaluate the relationship between CYP1A1 gene rs1048943 polymorphism and the risk of Iraqi men with prostate cancer.
Methods:
In this research, we conducted a population-based approach that intersects high-throughput genotype information from different population of Iraq to estimate the frequency of genotypes associated with prostate cancer responsivenessOur study included a total of 100 patients and 150 healthy controls. rs1048943 genotyping has been investigated in Iraqi men in connection with prostate cancer.
Results:
We observed that individuals with the rs1048943 GA genotype had an increased risk of prostate cancer relative to those with the AA genotype ( OR 95% CI of 0.449 :95%CI 0.23-0.90; P = 0.002). We found in the dominant model that the rs1048943 GA and GG genotype displayed an increased risk of prostate cancer relative to the AA genotype ( OR 95% CI of 0.680 :95%CI 0.4-1.17; P = 0.018).
Conclusion:
Polymorphism RS 1048943 in the CYP1A1 gene is associated with the risk of developing prostate cancer and is possibly one of the most significant factors in its development.
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