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Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

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Published on: February 9, 2024

IGFBP-2 in cervical cancer development.

Gurjeet Kaur¹, Shandra Devi Balasubramaniam¹, Yung Jen Lee¹

¹Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia.

Experimental and Molecular Pathology

|December 25, 2019

Summary

Insulin-like growth factor binding protein 2 (IGFBP-2) is highly expressed in cervical cancer, suggesting an oncogenic role. This protein may drive cancer progression independently of the IGF pathway.

Keywords:

Cervical cancer Cervical intraepithelial neoplasia IGF-1 IGFBP-2

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Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Insulin-like growth factor binding protein 2 (IGFBP-2) is implicated in various cancers, but its function in cervical cancer remains unclear.
Investigating IGFBP-2 and its associated signaling pathway is crucial for understanding cervical carcinogenesis.

Purpose of the Study:

To examine the expression of IGFBP-2 protein in cervical cancer.
To analyze the transcriptomics profile of genes within the IGF signaling pathway during cervical cancer development.

Main Methods:

Immunohistochemistry was used to assess IGFBP-2 protein expression in normal cervix, low-grade cervical intraepithelial neoplasia (LGCIN), high-grade cervical intraepithelial neoplasia (HGCIN), and squamous cell carcinoma (SCC) tissues.
Human Transcriptome Array 2.0 was employed to determine gene expression profiles of IGFBP-2, IGF-1, IGF-1R, PTEN, MDM2, AKT1, and TP53 in cervical tissue samples.

Main Results:

IGFBP-2 protein expression was significantly higher in SCC compared to normal cervix (p = 0.013).
TP53 and IGFBP-2 genes were upregulated in HGCIN and SCC.
IGF-1, IGF-1R, and PTEN genes showed downregulation across histological groups, with significant downregulation of IGF-1 in SCC (p = 0.031) and PTEN in HGCIN (p = 0.012).
MDM2 and AKT1 genes were downregulated in LGCIN and HGCIN but upregulated in SCC.

Conclusions:

IGFBP-2 likely plays an oncogenic role in cervical carcinogenesis.
The oncogenic function of IGFBP-2 may operate through a mechanism independent of the IGF signaling pathway.