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Rebecca K Lee1, Robert P Shrewsbury1

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Direct observational scores did not predict the potency of pharmacy students' compounded sterile preparations (CSPs). Potency analysis revealed critical training gaps in aseptic technique, particularly with vial manipulation.

Keywords:
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Area of Science:

  • Pharmaceutical Sciences
  • Pharmacy Education

Background:

  • Compounded sterile preparations (CSPs) require strict aseptic technique.
  • Assessing student competency in aseptic technique is crucial for patient safety.

Purpose of the Study:

  • To evaluate if direct observational scores correlate with the potency of pharmacy students' CSPs.
  • To identify student misunderstandings in aseptic technique steps.

Main Methods:

  • First-year pharmacy students performed aseptic techniques in three encounters: vial, ampule, and reconstitution transfers to IV bags.
  • Student performances were assessed via an observation rubric and subjected to potency analysis.

Main Results:

  • Mean potencies for diphenhydramine (vial) and lidocaine (ampule) met goals, unlike ampicillin (reconstitution).
  • Observation scores did not correlate with CSP potency, despite up to 50% of students failing potency goals.
  • Students demonstrated inadequate training in managing vial pressurization during aseptic compounding.

Conclusions:

  • Potency analysis is essential for evaluating aseptic compounding skills, revealing issues missed by observational scores alone.
  • A combined assessment of observational scores and potency analysis is recommended for comprehensive evaluation of student competency.