Phase-based T₂ mapping with gradient echo imaging

Transverse relaxation time (T₂ ) mapping with MRI has a plethora of clinical and research applications. Current T₂ mapping techniques are based primarily on spin-echo (SE) relaxometry strategies that rely on the signal magnitude, and often suffer from lengthy acquisition times. In this work, we propose a phase-based T₂ mapping technique where T₂ information is encoded into the signal phase of rapid gradient echo (GRE) acquisitions.

Bloch equation simulations demonstrate that the phase of GRE acquisitions obtained with a very small inter-repetition RF phase increment has a strong monotonic dependence on T₂ , resulting from coherent transverse magnetization. This T₂ -dependent phase behavior forms the basis of the proposed T₂ mapping technique. To isolate T₂ -dependent phase from background phase, at least 2 data sets with different RF phase increments are acquired. The proposed method can also be combined with chemical shift encoded MRI to separate water and fat signals.

The feasibility of the proposed technique was validated in a phantom experiment. In vivo feasibility was demonstrated in the brain, knee, abdomen, and pelvis. Comparisons were made with SE-based T₂ mapping, spectroscopy, and T₂ values from the literature.

The proposed method produced accurate T₂ maps compared with SE-based T₂ mapping in the phantom. Good qualitative agreement was observed in vivo between the proposed method and the reference. T₂ measured in various anatomies agreed well with values reported in the literature.

A phase-based T₂ mapping technique was developed and its feasibility demonstrated in phantoms and in vivo.