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Updated: Jan 1, 2026
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
A bioorthogonally activatable photosensitiser for site-specific photodynamic therapy
Yimin Zhou1, Roy C H Wong, Gaole Dai
1Department of Chemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, P. R. China. dkpn@cuhk.edu.hk.
Abstract:
A boron dipyrromethene based photosensitiser substituted with a 1,2,4,5-tetrazine moiety has been prepared of which the photoactivity can be activated upon an inverse-electron-demand Diels-Alder reaction with trans-cyclooctene derivatives. By using a biotin-conjugated trans-cyclooctene to tag the biotin-receptor-positive HeLa cells, this photosensitiser exhibits site-specific activation through cycloaddition, leading to high photocytotoxicity.
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