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Simplified Method to Determine the Efflux Ratio on P-Glycoprotein Substrates Using Three-Compartment Model Analysis

Miho Nagayasu1,2, Kazuhisa Ozeki3, Yuuji Sakurai1

  • 1Research division, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka, 412-8513, Japan.

Pharmaceutical Research
|December 25, 2019
PubMed
Abstract

Keywords:
Caco-2 cellsP-glycoproteindrug–drug interactionefflux ratiomodel analysis

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