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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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[Progress of Steroids Effect on Efficacy of Immune Checkpoint Inhibitors]

Guoqiang Pan1, Yun Fan2

  • 1Wenzhou Medical University, Wenzhou 325035, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|December 26, 2019
PubMed

Immune checkpoint inhibitors (ICIs), including programmed death receptor-1 (PD-1)/ligand (PD-L1) and cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) monoclonal antibody, have been approved for the treatment of multiple advanced malignant tumors, on account of its ideal antitumor activity. For patients receiving ICIs treatment, glucocorticoid intervention and treatment are often applied because of some complications associated with tumor, immunotherapy-related adverse reactions, and pretreatment before immunotherapy combined with chemotherapy. However, excessive physiological dose of glucocorticoid has a certain immunosuppressive effect, which may even affect the curative efficacy of ICIs. Thus, there are controversies about the use of steroids in patients receiving ICIs treatment. In this article, we reviewed the progress of steroids effect on the efficacy of ICIs.

Keywords:
Checkpoint inhibitorsImmunotherapySteroids

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