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Published on: August 19, 2020
Comparison of Bilateral Cerebro-Renal Tissue Oxygenations in Healthy Children
Nilüfer Yalındağ Öztürk1, Burcu Aygün2, Emel Uyar2
1Division of Pediatric Critical Care, Department of Pediatrics, Marmara University School of Medicine, Marmara University Pendik Training and Research Hospital, Fevzi Cakmak Mah, Mimar Sinan Cad, No 41 Ust Kaynarca Pendik, 34889, Pendik, İstanbul, Turkey. nilufer.ozturk@marmara.edu.tr.
Insights
Healthy children show no side differences in cerebral and renal tissue oxygenation. However, regional oxygenation varies with age, with renal oxygenation higher in older children and cerebral in younger ones.
Area of Science:
- Pediatric Physiology
- Medical Instrumentation
- Neurosurgery
Background:
- Cerebral tissue oxygenation (ctSO2) and renal tissue oxygenation (rtSO2) monitoring is crucial in pediatric care.
- Understanding regional oxygenation laterality in healthy children provides a baseline for critical care assessment.
Purpose of the Study:
- To investigate differences in right and left cerebral and renal tissue oxygenation in healthy children.
- To explore the relationship between age and regional oxygenation in pediatric patients.
Main Methods:
- An observational, cross-sectional study included 100 healthy outpatients.
- Bilateral cerebral tissue oxygenation (ctSO2) and renal tissue oxygenation (rtSO2) were measured simultaneously using the INVOS™ 5100 device.
Main Results:
- No significant differences were found in right versus left cerebral or renal tissue oxygenation (ctSO2, rtSO2) or in age-related lateralization.
- Renal oxygenation was higher than cerebral oxygenation in 63% of children.
- A significant age interaction was observed, with renal oxygenation exceeding cerebral in older children and vice versa in younger children.
Conclusions:
- Healthy children exhibit no lateralization in cerebral or renal tissue oxygenation.
- Age-dependent differences exist between cerebral and renal oxygenation levels.
- Findings aid in interpreting near-infrared spectroscopy (NIRS) data in pediatric populations, including critically ill patients.
Objective:
To investigate right and left cerebral tissue (ctSO2) and renal tissue oxygenations (rtSO2) in otherwise healthy children.
Methods:
In this observational cross-sectional study, one hundred children seen as outpatients for well child care or common non-critical complaints, were included. Bilateral ctSO2 and rtSO2 were recorded simultaneously with INVOS™ 5100 device.
Results:
The median age was 6.7 y (IQR 3-10.4) and median weight was 21 kg (IQR 13-33). Right and left sided ctSO2 and rtSO2 values were 78.7% ± 6.0% and 79.1% ± 5.7%; 81.5% ± 9.4% and 81.4% ± 9.5% respectively. There were no differences in right and left cerebral and renal near infrared spectroscopy (NIRS) values, and no age centered lateralization effect. Renal measurements were higher than cerebral counterparts in 63% of the children. Interaction between age and regional oxygenation was significant. For both sides, renal oxygenation was higher than that of cerebrum in older children, whereas the opposite held true with younger age.
Conclusions:
There are no right and left side differences in ctSO2 and rtSO2 values in otherwise healthy children. On the other hand, there seem to be differences between cerebral and renal regions with a significant age effect. Acknowledging its limitations, this study sheds light on laterality and cranial and renal NIRS measurements in otherwise healthy children, and may contribute to the interpretation of NIRS data in critically ill patients.
