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Hyperglycemia is a stress response in acute stroke
1Department of Medicine, University of Hong Kong, Queen Mary Hospital.
Stroke
|November 1, 1988
Summary
High blood glucose levels upon admission do not worsen stroke outcomes. Hyperglycemia in stroke patients may indicate a latent diabetic state or a stress response, not necessarily poor prognosis.
Area of Science:
- Neurology
- Endocrinology
- Clinical Chemistry
Background:
- Admission glucose levels are a potential prognostic factor in acute stroke.
- Previous studies have yielded conflicting results regarding hyperglycemia and stroke outcomes.
Purpose of the Study:
- To investigate the relationship between admission glucose, fructosamine, and glycosylated hemoglobin and stroke outcomes.
- To determine if hyperglycemia impacts mortality and neurologic outcome in different stroke subtypes.
Main Methods:
- 216 patients with first-time stroke admitted within 24 hours were assessed.
- Measured glucose, fructosamine (4-6 week glycemia), and glycosylated hemoglobin (3-month glycemia).
- Strokes classified as cortical infarction, lacunar infarction, or intracerebral hemorrhage.
Main Results:
- No correlation found between neurologic outcome/mortality and fructosamine or glycosylated hemoglobin.
- Admission glucose correlated significantly with survival only in patients with intracerebral hemorrhage.
- Exclusion of diabetic patients did not alter these findings.
Conclusions:
- Hyperglycemia is unlikely to negatively impact acute stroke outcomes.
- Elevated glucose levels may represent a stress response or undiagnosed diabetes.
- Further research is needed to clarify the role of hyperglycemia in stroke management.