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Rearrangement analysis of multiple bacterial genomes
Mehwish Noureen1,2, Ipputa Tada1,2, Takeshi Kawashima1,2
1National Institute of Genetics, Mishima, Shizuoka, 411-8540, Japan.
BMC Bioinformatics
|December 29, 2019
Summary
Genome rearrangements, like inversions, provide evolutionary insights. Comparing gene orders in Helicobacter pylori strains identified shared and unique reversals, aiding phylogenetic reconstruction.
Area of Science:
- Genomics
- Evolutionary Biology
- Microbial Genetics
Background:
- Genomes undergo rearrangements, such as inversions, influencing gene order during evolution.
- Gene order changes are rarer than point mutations, offering robust phylogenetic data.
- Helicobacter pylori presents a unique model for studying evolution in specific environments.
Purpose of the Study:
- To develop a method for identifying genome rearrangements by comparing gene orders.
- To analyze evolutionary relationships using gene order data in Helicobacter pylori.
Main Methods:
- Developed a novel method to detect genome rearrangements.
- Utilized orthologous gene clusters for gene order alignment.
- Compared gene orders across 72 Helicobacter pylori strains.
Main Results:
- Identified both shared and strain-specific gene reversals in Helicobacter pylori.
- Observed that some reversals were geographically distributed.
- Demonstrated the utility of gene order comparison for large-scale genome analysis.
Conclusions:
- Genome rearrangement rates increase over evolutionary time.
- Gene order is a valuable marker for studying evolutionary relationships.
- Comparative genomics of gene order reveals strain-specific and shared evolutionary events.
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