Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

87.6K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
87.6K
Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

8.8K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....
8.8K
Sanger Sequencing01:57

Sanger Sequencing

753.0K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
753.0K
Nucleic Acids02:43

Nucleic Acids

7.5K
7.5K
Nucleic acids02:43

Nucleic acids

160.1K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
160.1K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

3.9K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonizing standards and resources for the medical genome.

Nature·2026
Same author

How can biological databases support the new UN mechanism for benefit-sharing from digital sequence information?

Scientific data·2026
Same author

ATAC-seq of low-input and cryopreserved primordial germ cells reveals functional enhancers.

Development (Cambridge, England)·2026
Same author

The European Nucleotide Archive in 2025.

Nucleic acids research·2025
Same author

MarpolBase: genome database for Marchantia polymorpha featuring high quality reference genome sequences.

Plant & cell physiology·2025
Same author

DDBJ update in 2025: system integration for global data-sharing including pathogen surveillance.

Nucleic acids research·2025

Related Experiment Video

Updated: Jun 7, 2025

The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

30.7K

The international nucleotide sequence database collaboration (INSDC): enhancing global participation.

Ilene Karsch-Mizrachi1, Masanori Arita2, Tony Burdett3

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Research
|November 13, 2024
PubMed
Summary

The International Nucleotide Sequence Database Collaboration (INSDC) aims to expand its global reach. This initiative promotes open science and data sharing for broader innovation in genomics.

More Related Videos

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

33.6K
Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
10:40

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

10.4K

Related Experiment Videos

Last Updated: Jun 7, 2025

The ITS2 Database
16:17

The ITS2 Database

Published on: March 12, 2012

30.7K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

33.6K
Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
10:40

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

Published on: December 22, 2017

10.4K

Area of Science:

  • Bioinformatics
  • Genomics
  • Data Science

Background:

  • The International Nucleotide Sequence Database Collaboration (INSDC) has managed sequence data for over 40 years.
  • Founding members include NLM-NCBI (USA), ROIS-NIG (Japan), and EMBL-EBI (Europe).
  • A formal arrangement ensures free and open access to genomic sequences.

Purpose of the Study:

  • To expand the INSDC to be more globally representative.
  • To advance open science and data sharing through diversified participation.
  • To incorporate diverse perspectives in emerging data management areas.

Main Methods:

  • Formalizing collaborative arrangements.
  • Expanding membership to a global community.
  • Exploring new data management strategies.

Main Results:

  • Commitment to free and open access to genomic sequences.
  • Initiation of expansion to increase global representation.
  • Anticipation of benefits from diverse perspectives in data management.

Conclusions:

  • Expanding INSDC membership will foster greater innovation.
  • Diversified participation enhances open science and data sharing.
  • New perspectives will aid in addressing challenges in data federation, attribution, and management.