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Updated: Jan 9, 2026

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

Published on: September 3, 2009

The European Nucleotide Archive in 2025.

Yuan David¹, Ahamed Alisha¹, Athar Awais¹

¹European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, United Kingdom.

Nucleic Acids Research

|December 3, 2025

Summary

This summary is machine-generated.

The European Nucleotide Archive (ENA) advances FAIR data principles in 2025 with technical upgrades and global initiatives. It enhances infrastructure for nucleotide sequence data, improving accessibility and reuse for researchers worldwide.

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Area of Science:

Bioinformatics
Genomics
Data Science

Background:

The European Nucleotide Archive (ENA) is a critical global resource for nucleotide sequence data.
Maintaining open access and FAIR data principles is essential for scientific advancement.

Purpose of the Study:

To report key developments and infrastructure enhancements at ENA in 2025.
To highlight ENA's commitment to FAIR data principles and global engagement.

Main Methods:

Technical transformation and infrastructure upgrades.
Development of enhanced support for large-scale biodiversity projects.
Implementation of the International Nucleotide Sequence Database Collaboration Global Participation Initiative.

Main Results:

Progress in technical transformation for scalability and interoperability.
Improved support for biodiversity data, accommodating exponential growth.
Enhanced user experience and data discovery capabilities.

Conclusions:

ENA continues to evolve as a leading platform for nucleotide sequence data.
Innovations in 2025 strengthen ENA's role in global genomics research and data sharing.