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Related Experiment Video

Updated: Jan 1, 2026

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

Investigating host-bacterial interactions among enteric pathogens.

Tungadri Bose^1,2, K V Venkatesh², Sharmila S Mande³

¹Bio-Sciences R&D Division, TCS Innovation Labs, Tata Consultancy Services Limited, Pune, India.

|December 29, 2019

Summary

This summary is machine-generated.

This study identifies common and unique host-pathogen protein interactions in gut pathogens like Escherichia, Shigella, Salmonella, and Vibrio. These findings aid in understanding pathogen survival and developing new therapies against antibiotic-resistant infections.

Keywords:

Gut pathogens Host pathogen interactions Protein interaction networks Therapeutic targets

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Published on: April 9, 2019

Area of Science:

Microbiology
Infectious Diseases
Bioinformatics

Background:

Antibiotic-resistant pathogens pose a significant global health threat.
Six priority pathogens identified by the WHO infect the human gastrointestinal system.
Gut microbiome dysbiosis by these pathogens impacts human physiology and immunity.

Purpose of the Study:

To identify virulence mechanisms of enteric pathogens.
To understand host-pathogen interactions in the gut.
To inform the development of novel therapeutic strategies.

Main Methods:

In silico evaluation of Host-Pathogen Protein-Protein Interaction (HPI) profiles.
Comparative analysis of four enteric pathogen groups: Escherichia, Shigella, Salmonella, and Vibrio.

Main Results:

A common repertoire of HPIs was identified across most enteric pathogens, crucial for gut survival.
Genus/species-specific HPIs were also observed, indicating unique adaptations.
Variations in HPI profiles correlate with pathogen virulence.

Conclusions:

Identified bacterial proteins in core HPIs enhance understanding of gut pathogen pathogenesis.
Genus/species-specific HPI variations contribute to pathogen virulence.
Results offer opportunities for developing novel therapeutics against critical gut pathogens.