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The Association of MMP7 Genotype With Pterygium

Pei-Shin Hu1,2,3, Yun-Chi Wang3, Cheng-Hsi Liao1,3,4

  • 1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

In Vivo (Athens, Greece)
|December 29, 2019
PubMed
Abstract

Insights

Matrix metalloproteinase-7 (MMP7) promoter genotypes A-181G and C-153T do not influence pterygium risk in Taiwanese individuals. This study found no significant association between these MMP7 genetic variations and pterygium susceptibility.

Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Background:

  • Pterygium formation is linked to extracellular matrix imbalance.
  • Matrix metalloproteinases (MMPs) are implicated in pterygium pathogenesis.
  • Limited research exists on MMPs' diagnostic or prognostic value in pterygium.

Purpose of the Study:

  • To investigate the association between matrix metalloproteinase-7 (MMP7) promoter polymorphisms (A-181G and C-153T) and pterygium risk.
  • To determine if specific MMP7 genotypes contribute to pterygium development in a Taiwanese population.

Main Methods:

  • Case-control study involving 134 pterygium cases and 268 controls.
  • Genotyping of MMP7 promoter A-181G and C-153T polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Main Results:

  • No significant differential distribution of MMP7 A-181G genotypes (AA, AG, GG) was observed between pterygium cases and controls (p for trend=0.6822).
  • No polymorphic genotypes for MMP7 C-153T were found in the Taiwanese cohort studied.

Conclusions:

  • The studied MMP7 promoter genotypes (A-181G and C-153T) do not appear to play a direct role in determining susceptibility to pterygium in the Taiwanese population.
  • Further research may be needed to explore other genetic or environmental factors contributing to pterygium development.
Keywords:
AgeMMP7Taiwangendergenotypepolymorphismpterygium

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