Toxic effects of Crotalaria saltiana in mice

Dry Crotalaria saltiana shoots were fed to strain ASL mice at 50, 10 and 1% of the diet. Feeding of Crotalaria shoots at 50 and 10% produced toxicity and death after 7 to 29 days. The signs of Crotalaria poisoning were inappetence, dullness, dyspnea and recumbency. The main lesions were necrosis, portal fibroplasia and hemorrhage in the liver, pulmonary congestion and emphysema, focal catarrhal enteritis, and degeneration of the cells of the renal tubules.