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Andrographolide: Chemical modification and its effect on biological activities
Gulshan Kumar1, Davinder Singh2, Javeed Ahmad Tali2
1Bio-organic Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.
Bioorganic Chemistry
|December 30, 2019
Summary
Andrographolide, a natural compound from Andrographis paniculata, shows diverse biological activities. This review focuses on its chemical modifications and enhanced bioavailability for drug development.
Area of Science:
- Phytochemistry
- Medicinal Chemistry
- Pharmacology
Background:
- Andrographolide (1) is a key bioactive compound from Andrographis paniculata (AP).
- It exhibits a wide range of biological activities, including anti-cancer, anti-diabetic, and anti-inflammatory properties.
- Existing literature lacks a consolidated review on the chemical modifications of andrographolide and their impact on biological activities.
Purpose of the Study:
- To review the chemical modifications of andrographolide (1) from 2009 onwards.
- To correlate these modifications with specific biological activities.
- To explore strategies for enhancing andrographolide's bioavailability through targeted drug delivery systems.
Main Methods:
- Comprehensive literature search for studies published from 2009 to present.
- Analysis of chemical modification strategies applied to andrographolide.
- Evaluation of reported biological activities linked to modified andrographolide derivatives.
- Review of approaches for improving andrographolide bioavailability.
Main Results:
- Numerous chemical modifications of andrographolide have been reported, targeting various functional groups.
- Specific modifications have led to enhanced or novel biological activities.
- Strategies for improving bioavailability, such as nanoformulations and prodrugs, are being developed.
Conclusions:
- Chemical modification is a promising strategy to optimize andrographolide's therapeutic potential.
- Further research into structure-activity relationships and bioavailability enhancement is crucial.
- Andrographolide derivatives hold significant promise for developing new therapeutic agents.
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