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Bisphenols and Thyroid Hormone.

Min Joo Kim1, Young Joo Park2

  • 1Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.

Endocrinology and Metabolism (Seoul, Korea)
|December 30, 2019
PubMed
Summary

Bisphenol A (BPA) exposure is linked to thyroid disruption in humans. This review explores BPA

Keywords:
Bisphenol AEndocrine disruptorsReceptors, thyroid hormoneThyroid hormones

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Area of Science:

  • Endocrinology
  • Environmental Health
  • Toxicology

Background:

  • Bisphenol A (BPA) is an endocrine disruptor with known estrogenic activity.
  • Emerging evidence suggests BPA interferes with thyroid hormone function.

Purpose of the Study:

  • To review human epidemiological studies on BPA exposure and thyroid hormone levels.
  • To analyze in vivo and in vitro data for causal links and mechanisms of BPA's thyroid disruption.
  • To examine the impact of other bisphenols on thyroid hormone action.

Main Methods:

  • Systematic review of human epidemiological studies.
  • Analysis of in vivo and in vitro experimental data.
  • Literature review on alternative bisphenols.

Main Results:

  • BPA exposure is associated with altered thyroid hormone levels in humans.
  • BPA acts as a thyroid hormone receptor antagonist and affects thyroid action via multiple pathways.
  • Other bisphenols also demonstrate potential to disrupt thyroid hormone action.

Conclusions:

  • BPA significantly impacts thyroid hormone homeostasis and action through various mechanisms.
  • The widespread use of alternative bisphenols warrants further investigation into their endocrine-disrupting potential.