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Thiram - Toxic inhalational lung injury
Jan Siwiec1, Elżbieta Siek2, Anna Grzywa-Celińska1
1Chair and Department of Pneumonology, Oncology and Allergology, Medical University, Lublin, Poland.
Annals of Agricultural and Environmental Medicine : AAEM
|December 31, 2019
Summary
Thiram fungicide exposure caused acute respiratory failure in a patient. Systemic corticosteroids effectively treated the lung condition, resolving the patient's symptoms.
Area of Science:
- Toxicology
- Pulmonary Medicine
- Environmental Health
Background:
- Thiram, a widely used fungicide and rubber industry chemical, poses respiratory risks.
- Metabolism of thiram leads to toxic byproducts like carbon disulfide.
- Acute respiratory failure is a potential, severe adverse effect of thiram exposure.
Observation:
- A 45-year-old woman presented with acute respiratory failure.
- Computed tomography revealed extensive ground-glass opacities in both lungs.
- Cardiac assessment showed significant enlargement of both atria.
Findings:
- Initial cardiac treatment did not improve the patient's respiratory status.
- Systemic corticosteroid therapy led to successful treatment of the pulmonary condition.
- The patient was subsequently managed in the pulmonary out-patient department.
Implications:
- This case highlights the severe pulmonary toxicity of thiram.
- Prompt diagnosis and corticosteroid treatment are crucial for managing thiram-induced respiratory failure.
- Further research into thiram's toxicological mechanisms and preventative strategies is warranted.
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