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Resolution of Osseous Sarcoidosis with Methotrexate
Christopher Kanner1, Bonita Libman1, Morgan Merchand1
1University of Vermont Medical Center, The Robert Larner, M. D. College of Medicine at the University of Vermont, Burlington, VT, USA.
Case Reports in Rheumatology
|December 31, 2019
Summary
Methotrexate effectively treated a rare case of widespread skeletal sarcoidosis. This approach led to significant clinical improvement and near-complete resolution of imaging abnormalities on MRI.
Area of Science:
- Rheumatology
- Oncology
- Radiology
Background:
- Osseous sarcoidosis, a rare manifestation, presents management challenges with no established optimal treatment.
- Previous treatments for skeletal sarcoidosis show variable efficacy, often assessed via imaging and clinical evaluation.
Observation:
- A patient presented with widespread skeletal sarcoidosis but no concurrent pulmonary disease.
- Magnetic resonance imaging (MRI) was used to monitor disease progression and treatment response.
Findings:
- Methotrexate monotherapy demonstrated significant clinical improvement in the patient.
- Near-complete resolution of skeletal abnormalities was observed on MRI following methotrexate treatment.
Implications:
- This case suggests methotrexate may be a viable primary treatment for osseous sarcoidosis.
- Further research is warranted to establish methotrexate's role in managing skeletal sarcoidosis.
