Honeycomb-like pH-responsive γ-cyclodextrin electrospun particles for highly efficient tumor therapy

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Nanotechnology

Background:

• Developing effective drug delivery systems for cancer therapy is crucial.
• pH-responsive materials offer targeted drug release in acidic tumor microenvironments.
• Microparticle-based implants provide localized and sustained drug delivery.

Purpose of the Study:

• To develop and characterize novel tumor-implantable microparticles with a honeycomb-like porous structure.
• To investigate the pH-triggered drug release mechanism of these microparticles.
• To evaluate the efficacy of these microparticles as a chemotherapeutic implant for tumor therapy.

Main Methods:

• Electrospinning of gamma-cyclodextrin (γ-CD) conjugated with 3-(diethylamino)propylamine (DEAP) to form γ-CD-DEAP microparticles.
• Paclitaxel (PTX) encapsulation using a simple hole-filling method.
• In vitro and in vivo studies to assess pH-triggered PTX release and tumor cell ablation.
• Characterization of microparticle structure and drug release kinetics at different pH values.

Main Results:

• Honeycomb-like porous γ-CD-DEAP microparticles were successfully fabricated.
• Efficient PTX entrapment was achieved within the microparticle pores.
• Acidic pH (6.8) induced protonation of DEAP, leading to particle destruction and PTX release.
• Implanted γ-CD-DEAP microparticles demonstrated enhanced in vitro and in vivo tumor cell ablation.

Conclusions:

• γ-CD-DEAP microparticles exhibit pH-triggered destruction and drug release capabilities.
• These microparticles serve as effective tumor-implantable chemotherapeutic delivery systems.
• The developed microparticles show significant potential for improving tumor therapy outcomes.