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Honeycomb-like pH-responsive γ-cyclodextrin electrospun particles for highly efficient tumor therapy.

Hyeong Sup Yu1, Eun Seong Lee2

  • 1Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Gyeonggi-do 14662, Republic of Korea.

Carbohydrate Polymers
|January 1, 2020
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Summary

New honeycomb-like microparticles release chemotherapy drugs in response to tumor acidity. These tumor-implantable particles enhance cancer cell destruction, showing promise for advanced cancer therapy.

Keywords:
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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Developing effective drug delivery systems for cancer therapy is crucial.
  • pH-responsive materials offer targeted drug release in acidic tumor microenvironments.
  • Microparticle-based implants provide localized and sustained drug delivery.

Purpose of the Study:

  • To develop and characterize novel tumor-implantable microparticles with a honeycomb-like porous structure.
  • To investigate the pH-triggered drug release mechanism of these microparticles.
  • To evaluate the efficacy of these microparticles as a chemotherapeutic implant for tumor therapy.

Main Methods:

  • Electrospinning of gamma-cyclodextrin (γ-CD) conjugated with 3-(diethylamino)propylamine (DEAP) to form γ-CD-DEAP microparticles.
  • Paclitaxel (PTX) encapsulation using a simple hole-filling method.
  • In vitro and in vivo studies to assess pH-triggered PTX release and tumor cell ablation.
  • Characterization of microparticle structure and drug release kinetics at different pH values.

Main Results:

  • Honeycomb-like porous γ-CD-DEAP microparticles were successfully fabricated.
  • Efficient PTX entrapment was achieved within the microparticle pores.
  • Acidic pH (6.8) induced protonation of DEAP, leading to particle destruction and PTX release.
  • Implanted γ-CD-DEAP microparticles demonstrated enhanced in vitro and in vivo tumor cell ablation.

Conclusions:

  • γ-CD-DEAP microparticles exhibit pH-triggered destruction and drug release capabilities.
  • These microparticles serve as effective tumor-implantable chemotherapeutic delivery systems.
  • The developed microparticles show significant potential for improving tumor therapy outcomes.