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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Dec 31, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

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Liver Cancer: Current and Future Trends Using Biomaterials.

Sue Anne Chew1, Stefania Moscato2,3, Sachin George1

  • 1Department of Health and Biomedical Sciences, University of Texas Rio Grande Valley, One West University Blvd., Brownsville, TX 78520, USA.

Cancers
|January 1, 2020
PubMed
Summary
This summary is machine-generated.

Biomaterials offer versatile solutions for treating and studying hepatocellular carcinoma (HCC), a deadly liver cancer. Innovations in biomaterial-based therapies and 3D models show promise for improved HCC treatment and research.

Keywords:
3D modelsbiomaterialshepatocellular carcinomaimmunotherapymicroparticlesnanoparticlesscaffolds

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Area of Science:

  • Biomaterials Science
  • Oncology
  • Regenerative Medicine

Background:

  • Hepatocellular carcinoma (HCC) is a major global health concern, ranking fifth in cancer diagnoses and second in cancer-related deaths.
  • Current HCC treatments have limitations, resulting in unfavorable patient prognoses.
  • Biomaterials present a promising avenue for developing advanced therapeutic and research tools for liver cancer.

Purpose of the Study:

  • To provide a comprehensive review of current biomaterial applications in the study and treatment of hepatocellular carcinoma.
  • To highlight the versatility of biomaterials as smart tools in managing liver cancer.
  • To discuss novel biomaterial-based strategies for both systemic and local delivery of therapeutic agents.

Main Methods:

  • Review of existing literature on biomaterial applications for HCC treatment and research.
  • Analysis of biomaterial-based systemic delivery systems and implantable tools for local administration.
  • Discussion of specific therapies, targeting agents, and innovative approaches like combined therapies and cell capture.
  • Exploration of biomaterials in engineering 3D in vitro models for studying HCC tumor microenvironments.

Main Results:

  • Biomaterials are effectively utilized for both systemic and local delivery of bioactive factors in HCC treatment.
  • Novel biomaterial-based 3D in vitro models are being developed to better represent the HCC tumor environment.
  • Innovative strategies such as combined delivery and cell capture demonstrate potential for future HCC therapies.

Conclusions:

  • Biomaterials offer a versatile platform for advancing hepatocellular carcinoma treatment and research.
  • Engineered 3D in vitro models using biomaterials are crucial for understanding HCC biology and testing new therapies.
  • Emerging biomaterial-based approaches hold significant promise for improving outcomes in liver cancer management.