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Updated: Dec 31, 2025

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
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Comparing the Diagnostic Value of the C-Reactive Protein to Albumin Ratio With Other Inflammatory Markers in Patients

Zulkif Tanriverdi1, Fatih Gungoren1, Mustafa Begenc Tascanov1

  • 1Department of Cardiology, Faculty of Medicine, Harran University, Sanliurfa, Turkey.

Angiology
|January 1, 2020
PubMed

Insights

The C-reactive protein to albumin ratio (CAR) shows the highest diagnostic value in detecting significant coronary artery disease (CAD) compared to other inflammatory markers. CAR, along with age, independently predicts significant CAD.

Area of Science:

  • Cardiology
  • Inflammation Markers
  • Biochemistry

Background:

  • Inflammatory processes are crucial in cardiovascular risk assessment.
  • Novel inflammatory markers are needed for better detection of coronary artery disease (CAD).
  • The C-reactive protein to albumin ratio (CAR) is a potential inflammatory marker requiring further clinical validation in CAD.

Purpose of the Study:

  • To compare the diagnostic value of CAR with other inflammatory markers in detecting significant CAD.
  • To identify independent predictors of significant CAD.

Main Methods:

  • A study included 421 patients with stable angina pectoris undergoing coronary angiography.
  • Measured inflammatory markers included CAR, Neutrophil to Lymphocyte Ratio (NLR), Monocyte to Lymphocyte Ratio (MLR), and others.
  • Compared marker levels and diagnostic accuracy (Area Under the Curve - AUC) between patients with and without significant CAD.

Main Results:

  • Patients with significant CAD exhibited higher NLR, MLR, uric acid, monocyte to HDL-C ratio, and CAR.
  • CAR demonstrated the highest AUC for predicting significant CAD among all evaluated inflammatory parameters.
  • Age and CAR were identified as independent predictors of significant CAD via multivariate analysis.

Conclusions:

  • CAR possesses the strongest diagnostic capability for detecting significant CAD among the studied inflammatory markers.
  • CAR represents a valuable and independent predictor of significant CAD.
  • Further research may elucidate CAR's role in managing cardiovascular disease.

Keywords:
C-reactive protein to albumin ratiocoronary artery diseaseinflammatory markers

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