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Prognostic capacity of the leuko-glycemic index in cardiac syndrome Y

Muhammed Bahadır Omar1, Emre Eynel1, Sena Nasif1

  • 1Umraniye Training and Research Hospital, MD, Department of Cardiology, İstanbul, Turkey.

Science Progress
|July 21, 2025
PubMed

Insights

The leuko-glycemic index (LGI) can predict Cardiac Syndrome Y (CSY), a condition of coronary vasculature opacification. Elevated LGI levels indicate a higher risk of developing CSY, aiding in early detection.

Area of Science:

  • Cardiology
  • Biochemistry
  • Diagnostic Medicine

Background:

  • Cardiac Syndrome Y (CSY) involves gradual distal coronary vasculature opacification.
  • The leuko-glycemic index (LGI) combines blood glucose and white blood cell counts.
  • A link between LGI and CSY requires further investigation.

Purpose of the Study:

  • To investigate the relationship between the leuko-glycemic index (LGI) and Cardiac Syndrome Y (CSY).
  • To determine if LGI can predict the development of CSY.

Main Methods:

  • Retrospective case-control study including patients with angina.
  • Coronary angiography used to classify subjects into normal coronary flow (NCF) and coronary slow flow (CSF) groups.
  • Analysis of hematocrit, hemoglobin, white blood cells, and LGI.

Main Results:

  • The CSY group showed significantly higher hematocrit, hemoglobin, white blood cells, and LGI compared to the NCF group (P < .001).
  • CSY was positively correlated with hematocrit, hemoglobin, and white blood cells (P < .001).
  • ROC analysis identified an LGI cut-off value of ≥9.28 for predicting CSF with 78% sensitivity and 78.1% specificity (AUC: 0.626).

Conclusions:

  • Elevated LGI levels independently predict the formation of coronary slow flow (CSF).
  • This study establishes LGI as a potential biomarker for subclinical CSY development.

Keywords:
Coronary slow flow phenomenonTIMI frame countinexpensive indicatorthe leuko-glycemic index

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