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Sleep-disordered breathing in cystic fibrosis pediatric subjects

Magali Santos Lumertz1, Leonardo Araujo Pinto1

  • 1PUCRS, Pediatric Pulmonology - Porto Alegre - RS - Brazil.

Sleep Science (Sao Paulo, Brazil)
|January 1, 2020
PubMed

Insights

Sleep-disordered breathing (SDB) is common in children with cystic fibrosis (CF). Markers of CF lung disease severity correlate with sleep breathing issues, highlighting the importance of sleep studies.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Cystic Fibrosis Research

Background:

  • Sleep-disordered breathing (SDB) is a potential complication in pediatric cystic fibrosis (CF).
  • Assessing SDB and its relationship with CF progression is crucial for patient management.

Purpose of the Study:

  • To determine the prevalence of SDB in pediatric CF patients.
  • To investigate associations between polysomnographic respiratory parameters and clinical data in CF.

Main Methods:

  • Retrospective, cross-sectional study utilizing patient chart data from 2015-2016.
  • Included pediatric CF patients (2-20 years) with recent polysomnography records.
  • Defined SDB as apnea-hypopnea index >1 event/hour or SpO2 nadir <90%.

Main Results:

  • SDB was identified in 62.5% of the 16 included CF patients (mean age 11 years).
  • Forced expiratory volume in 1 second (FEV1) correlated with mean sleep SpO2 (r=0.602, p=0.023) and negatively with peak end-tidal CO2 (r=-0.645, p=0.024).
  • Pseudomonas aeruginosa colonization was linked to mean non-REM sleep EtCO2 (p=0.024).

Conclusions:

  • SDB is frequent in pediatric CF patients.
  • Clinical markers of CF respiratory disease are associated with sleep breathing parameters.
  • Sleep studies, including CO2 monitoring, are valuable for assessing respiratory status in CF.
Abstract

Keywords:
Cystic FibrosisPediatricsPolysomnographSleep Apnea Syndromes

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