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Updated: Dec 31, 2025

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
Wide-field angiography in retinal vein occlusions
Colin S Tan1,2,3,4, Kelvin Z Li1, SriniVas R Sadda5
11National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Jalan Tan Tock Seng, 11, Singapore, 308433 Singapore.
Ultra-widefield imaging (UWF) is crucial for assessing retinal vein occlusion (RVO). It effectively detects peripheral retinal non-perfusion, a key factor in RVO complications and treatment response.
Area of Science:
- Ophthalmology
- Retinal Vascular Diseases
- Medical Imaging
Background:
- Retinal vein occlusion (RVO) is a leading cause of vision loss, second only to diabetic retinopathy.
- Complications include macular edema, neovascularization, and vitreous hemorrhage.
- Ultra-widefield imaging (UWF) offers advanced posterior pole visualization for RVO evaluation.
Purpose of the Study:
- To highlight the utility of UWF imaging in RVO assessment.
- To emphasize the importance of detecting peripheral retinal pathologies in RVO.
- To explore the role of UWF in evaluating retinal non-perfusion.
Main Methods:
- Utilizing ultra-widefield (UWF) imaging to visualize up to 200° of the retina.
- Assessing peripheral retinal pathologies, particularly retinal non-perfusion in RVO.
- Employing techniques like ischemic index and stereographic projection to quantify ischemia.
Main Results:
- UWF imaging enables detection of peripheral retinal non-perfusion, a risk factor for neovascularization.
- Retinal non-perfusion identified via UWF impacts RVO complications like macular edema and neovascularization.
- Non-perfusion assessment influences disease response, visual acuity, and treatment needs.
Conclusions:
- UWF imaging is vital for assessing and managing RVO.
- It plays a key role in quantifying peripheral retinal non-perfusion.
- This enhances understanding of RVO pathology and treatment strategies.
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