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Related Concept Videos

Sample Preparation for Analysis: Overview01:21

Sample Preparation for Analysis: Overview

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Sample preparation is an essential step in the analytical process. It involves preparing a sample so that it can be analyzed accurately. The goal is to extract the analyte, the substance you want to measure, from the sample while removing any components that may interfere with the analysis. Sample preparation techniques vary depending on the physical state of the sample.
Bulk or large solid samples are typically reduced in size using grinding, crushing, or milling techniques to increase the...
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Capillary Electrophoresis: Applications01:30

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Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
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Size-Exclusion Chromatography01:08

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In size-exclusion chromatography (SEC), also known as molecular-exclusion or gel-permeation chromatography, molecules are separated based on their sizes. This technique is important for separating large molecules such as polymers and biomolecules. The two classes of micron-sized stationary phases encountered in SEC are silica particles and cross-linked polymer resin beads. Both materials are porous, but their pore sizes vary significantly.
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A Simple Fractionated Extraction Method for the Comprehensive Analysis of Metabolites, Lipids, and Proteins from a Single Sample
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Microextraction approaches for bioanalytical applications: An overview.

Mohamed Abdel-Rehim1, Stig Pedersen-Bjergaard2, Abbi Abdel-Rehim3

  • 1Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, SE 17176 Solna, Sweden; Functional Materials Group, Department of Applied Physics, School of Engineering Sciences, KTH Royal Institute of Technology, SE-164 40 Stockholm, Sweden.

Journal of Chromatography. A
|January 2, 2020
PubMed
Summary
This summary is machine-generated.

High-throughput sample preparation is crucial for bioanalysis due to complex biological matrices. This review explores miniaturized, automated techniques like microextraction, focusing on green chemistry principles and 3D printing applications.

Keywords:
3D printingBioanalysisMicroextraction approachesNanomaterialsSample preparation

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Area of Science:

  • Analytical Chemistry
  • Biochemistry
  • Forensic Science

Background:

  • Biological samples present complex matrices, necessitating effective sample preparation for accurate instrumental analysis.
  • Increasing sample volumes in drug development, forensics, and clinical assays demand high-throughput methods.

Purpose of the Study:

  • To review recent trends and novel strategies in sample preparation for bioanalysis.
  • To highlight miniaturized, automated, and green chemistry-aligned approaches.
  • To discuss the role of sorptive and liquid-phase microextraction, selective sorbents, and 3D printing.

Main Methods:

  • Review of recent scientific literature on sample preparation techniques.
  • Focus on sorptive microextraction and liquid-phase microextraction (LPME).
  • Consideration of selective sorbents and 3D printing in microextraction.

Main Results:

  • Miniaturization and automation are key drivers for high-throughput sample preparation.
  • Sorptive and liquid-phase microextraction techniques offer efficient analyte isolation from complex matrices.
  • Selective sorbents and 3D printing show promise for advanced microextraction applications.

Conclusions:

  • Novel sample preparation methods are essential to meet the growing demands of bioanalytical testing.
  • Microextraction techniques, particularly when miniaturized and automated, align with green chemistry principles.
  • Emerging technologies like 3D printing are poised to further enhance microextraction efficiency and applicability in bioanalysis.