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Daily exposure to forty percent oxygen causes a decrease in platelet count.

A F Meintjes1, R D Baynes, G G Rogers

  • 1Department of Physiology, University of Witwatersrand Medical School, Johannesburg, Republic of South Africa.

American Journal of Hematology
|December 1, 1988
PubMed
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Breathing 40% oxygen daily for six weeks significantly lowered circulating platelet counts (PLT) in a study. This decrease, observed during rest, suggests a link between hyperoxia and reduced platelet levels.

Area of Science:

  • Exercise Physiology
  • Hematology

Background:

  • Previous laboratory observations suggested a link between hyperoxic training and decreased platelet counts.
  • Understanding the physiological impact of hyperoxia on hematological parameters is crucial.

Purpose of the Study:

  • To evaluate the effect of controlled hyperoxic air exposure on circulating platelet counts.
  • To investigate the relationship between hyperoxia duration and platelet count changes.

Main Methods:

  • Subjects breathed 40% oxygen for 30 minutes daily, 5 days a week, for 6 weeks.
  • Platelet counts (PLT) and plateletcrit (Pct) were monitored throughout the study period.
  • Statistical analysis was used to determine the significance and correlation of observed changes.

Main Results:

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  • A consistent fall in PLT was observed between the first and fifth day of each week (P < .01).
  • A progressive decline in PLT occurred over the 6 weeks, inversely correlated with hyperoxic exposure duration (rs = -0.886, P < .02).
  • The total decrease in PLT was 56 +/- 46 x 10(9) l(-1) (P < .025), mirrored by changes in Pct.

Conclusions:

  • Controlled exposure to 40% oxygen at rest leads to a significant decrease in circulating platelet counts.
  • The observed decrease in PLT was not attributed to hemodilution or reduced erythropoiesis.
  • The underlying mechanism and biological significance of hyperoxia-induced thrombocytopenia require further investigation.