Related Experiment Video
Updated: Dec 31, 2025
10:29
Experimental Methodology for Estimation of Local Heat Fluxes and Burning Rates in Steady Laminar Boundary Layer Diffusion Flames
Published on: June 1, 2016
12.3K
Thermodynamic Approaches in Flux Analysis.
Sabine Peres1,2, Vincent Fromion3
1LRI, Université Paris-Sud, CNRS, Université Paris-Saclay, 91405, Orsay, France. sabine.peres@lri.fr.
Methods in Molecular Biology (Clifton, N.J.)
|January 2, 2020
Summary
Constrained-based modeling (CBM) uses mass balance to analyze cellular metabolic networks. This review explores CBM approaches, including thermodynamic constraints, to address non-physical fluxes and inconsistencies.
Area of Science:
- Systems Biology
- Metabolic Engineering
- Computational Biology
Background:
- Cellular reaction networks adhere to fundamental mass and energy balance laws.
- Constrained-based modeling (CBM) is a primary computational method for analyzing metabolic network mass balance.
Purpose of the Study:
- To review diverse Constrained-based modeling (CBM) approaches.
- To discuss how different CBM methods address metabolic system challenges.
Main Methods:
- Stoichiometric analysis techniques, including elementary flux mode analysis and flux balance analysis.
- Integration of thermodynamic constraints into CBM frameworks.
- Review of various CBM methodologies and their problem-solving capabilities.
Main Results:
- CBM effectively models metabolic network mass balance.
- Thermodynamic constraints enhance CBM by identifying and eliminating non-physical fluxes.
- Different CBM approaches are suited for distinct metabolic modeling problems.
Conclusions:
- CBM, particularly with thermodynamic integration, is crucial for accurate metabolic network analysis.
- Understanding various CBM approaches aids in selecting appropriate methods for specific biological questions.
- This review provides a comprehensive overview of CBM strategies for metabolic systems.
Related Concept Videos
01:16Control Volume and System Representations
1.5K
Two key frameworks are employed to analyze mass, energy, and momentum transfer: the control volume approach and the system approach. These frameworks offer different perspectives, depending on whether the focus is on a specific region in space (control volume approach) or a defined mass of fluid (system approach).
The control volume approach considers a stationary region in space through which fluid flows. This region is bounded by a control surface. For instance, in the case of water...
The control volume approach considers a stationary region in space through which fluid flows. This region is bounded by a control surface. For instance, in the case of water...
1.5K
01:06Thermodynamic Systems
7.4K
A thermodynamic system is a set of objects whose thermodynamic properties are of interest. The system is considered to be embedded in its surroundings or the environment. The system and its environment can exchange heat and do work on each other through a boundary that separates them. However, the immediate surroundings of the system interact with it directly and therefore have a much stronger influence on its behavior and properties.
Consider an example of tea boiling in a kettle. The...
Consider an example of tea boiling in a kettle. The...
7.4K
01:15Electric Flux
9.6K
The concept of flux describes how much of something goes through a given area. More formally, it is the dot product of a vector field within an area. For a better understanding, consider an open rectangular surface with a small area that is placed in a uniform electric field. The larger the area, the more field lines go through it and, hence, the greater the flux; similarly, the stronger the electric field (represented by a greater density of lines), the greater the flux. On the other hand, if...
9.6K
01:26Thermodynamic Potentials
1.5K
Thermodynamic potentials are state functions that are extremely useful in analyzing a thermodynamic system. They have dimensions of energy. The four important thermodynamic potentials are internal energy, enthalpy, Helmholtz free energy, and Gibbs free energy. These thermodynamic potentials can be expressed using two of the following variables: pressure, volume, temperature, and entropy. These two variables are expressed as the rate of change of the thermodynamic potential with respect to other...
1.5K
01:21Path Between Thermodynamics States
3.8K
Consider the two thermodynamic processes involving an ideal gas that are represented by paths AC and ABC in Figure 1:
3.8K
01:23Maxwell's Thermodynamic Relations
4.3K
Maxwell's thermodynamic relations are very useful in solving problems in thermodynamics. Each of Maxwell's relations relates a partial differential between quantities that can be hard to measure experimentally to a partial differential between quantities that can be easily measured. These relations are a set of equations derivable from the symmetry of the second derivatives and the thermodynamic potentials.
All thermodynamic potentials are exact differentials. Therefore, their second-order...
All thermodynamic potentials are exact differentials. Therefore, their second-order...
4.3K